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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDH2
All Species:
52.12
Human Site:
Y253
Identified Species:
88.21
UniProt:
P40926
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P40926
NP_005909.2
338
35503
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Chimpanzee
Pan troglodytes
XP_001156205
338
35499
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Rhesus Macaque
Macaca mulatta
XP_001114888
374
39932
Y289
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Dog
Lupus familis
XP_849944
338
35431
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Cat
Felis silvestris
Mouse
Mus musculus
P08249
338
35593
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Rat
Rattus norvegicus
P04636
338
35665
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415765
351
36949
Y266
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Frog
Xenopus laevis
NP_001085326
338
35691
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
V
F
Zebra Danio
Brachydanio rerio
NP_998296
337
35401
Y252
S
A
T
L
S
M
A
Y
A
G
A
R
F
T
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650696
336
35299
Y253
S
A
T
L
S
M
A
Y
A
G
A
R
F
A
G
Honey Bee
Apis mellifera
XP_392478
338
35783
Y256
S
A
T
L
S
M
A
Y
A
G
A
R
F
G
F
Nematode Worm
Caenorhab. elegans
O02640
341
35101
L257
S
A
T
L
S
M
A
L
A
G
A
R
F
A
N
Sea Urchin
Strong. purpuratus
XP_792004
337
35239
Y255
S
A
T
L
S
M
A
Y
A
A
A
R
F
C
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SN86
403
42387
Y311
S
A
T
L
S
M
A
Y
A
A
A
R
F
V
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
85.8
93.1
N.A.
94.9
94.3
N.A.
N.A.
84.3
84
84.6
N.A.
58.8
65
56.8
68.3
Protein Similarity:
100
100
88.5
97
N.A.
98.2
97.9
N.A.
N.A.
91.1
92
93.1
N.A.
76.3
80.7
72.7
83.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
86.6
93.3
80
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
86.6
93.3
80
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
50.6
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
63.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
86.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
100
0
0
0
0
100
0
100
15
100
0
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
100
0
79
% F
% Gly:
0
0
0
0
0
0
0
0
0
86
0
0
0
8
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
100
0
0
0
8
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
100
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
% R
% Ser:
100
0
0
0
100
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
100
0
0
0
0
0
0
0
0
0
0
8
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
65
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
93
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _